From Disease to Drug

A step-by-step guide to discovering drug candidates for any disease using Humanity Pattern

3 proven workflows • Choose based on your starting point

Start with a Known Drug

You know a drug that works (even partially) for the disease

Difficulty:Easiest
Time:5 minutes
Success Rate:High

Start with a Protein Target

You know which protein/enzyme is involved in the disease

Difficulty:Moderate
Time:15 minutes
Success Rate:Medium-High

Start from Scratch

You only know the disease, not the drug or target

Difficulty:Advanced
Time:30-60 minutes
Success Rate:Medium

Case Study: Alzheimer's Disease

Starting Point: Known drug Donepezil (acetylcholinesterase inhibitor)

Workflow Used: Pathway #1 (Start with Known Drug)

Results: Found 23 similar compounds including:

  • Galantamine (FDA approved)
  • Rivastigmine (FDA approved)
  • 12 novel compounds with better predicted BBB permeability

Time: 8 minutes

Case Study: Cancer (CML)

Starting Point: Target protein BCR-ABL kinase

Workflow Used: Pathway #2 (Start with Protein Target)

Results: Starting from Imatinib pharmacophore:

  • Nilotinib (2nd generation, FDA approved)
  • Dasatinib (overcomes resistance)
  • 8 scaffold-hopped candidates for testing

Time: 15 minutes

Ready to Start?

Choose a workflow above and follow the step-by-step guide. Every tool you need is already built into the platform.

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