Protein Expression • Tissue Distribution • Disease Targets • Subcellular Localization
Explore protein expression data for 19,670 protein-coding genes across 44 normal human tissues, 17 cancer types, and 56 cell lines.
19,670
44
17
28M+
The Human Protein Atlas is a Swedish-based program mapping all human proteins in cells, tissues, and organs using integration of various omics technologies. It contains protein expression data for 19,670 protein-coding genes across 44 normal human tissues, 17 cancer types, and 56 cell lines.
Proprotein Convertase Subtilisin/Kexin Type 9
Regulates LDL cholesterol by promoting LDL receptor degradation. Loss-of-function mutations protect against heart disease.
Gain-of-function mutations cause severe hypercholesterolemia and early coronary artery disease.
Troponin T2, Cardiac Type
Gold standard biomarker for myocardial infarction. Elevated levels indicate cardiac muscle damage.
Mutations cause inherited cardiac disease with abnormal heart muscle thickening.
B-Lymphocyte Antigen CD19
CAR-T cell therapy targeting CD19 achieves 80-90% remission in refractory B-cell malignancies.
CD19-directed immunotherapy (CAR-T, BiTE) shows revolutionary efficacy in relapsed/refractory ALL.
KRAS Proto-Oncogene, GTPase
Mutated in 95% of pancreatic cancers. G12C/D/V mutations drive oncogenic signaling.
Mutated in 30% of lung adenocarcinomas. KRAS-G12C inhibitors show clinical efficacy.
Mutated in 40% of colorectal cancers. Predicts resistance to EGFR-targeted therapy.
Amyloid Beta Precursor Protein
Cleaved to produce amyloid-beta peptides that form neurotoxic plaques. Mutations cause early-onset familial AD.
Microtubule Associated Protein Tau
Hyperphosphorylated tau forms neurofibrillary tangles, correlating with cognitive decline.
Tau mutations cause inherited dementia with behavioral changes and neurodegeneration.
Alpha-Synuclein
Aggregates into Lewy bodies in dopaminergic neurons. Multiplications and point mutations cause familial PD.
Alpha-synuclein aggregation throughout cortex causes dementia with parkinsonism.
Superoxide Dismutase 1
Over 185 mutations cause familial ALS (20% of cases). Misfolded SOD1 is toxic to motor neurons.