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Lipidomics Platform

Comprehensive lipid species profiling for membrane biology, signaling lipids, and lipid-mediated diseases

Lipid Species

100,000+

Lipid Classes

8 Major

Disease Biomarkers

250+

Clinical Studies

2,500+

Lipidomics: Mapping the Lipid Landscape

Lipidomics comprehensively profiles lipid species across all major classes including glycerophospholipids, sphingolipids, glycerolipids, sterols, fatty acids, and their derivatives. Lipids serve as structural membrane components, energy stores, and signaling molecules that regulate inflammation, metabolism, and cell fate.

Technology Platforms

  • LC-MS/MS: High-resolution shotgun and targeted lipidomics
  • MALDI Imaging: Spatial lipidomics in tissue sections
  • Ion Mobility MS: Isomer separation and structural elucidation
  • Lipidomics Arrays: High-throughput lipid profiling

Key Applications

  • Cardiovascular Disease: Ceramide biomarkers for MACE prediction
  • Metabolic Disease: NAFLD, obesity, insulin resistance
  • Inflammation: Eicosanoids, specialized pro-resolving mediators
  • Neurodegeneration: Sphingolipid dysregulation in Alzheimer's

Lipidomics Workflow

1

Sample Collection

Blood, tissue, cells - rapid lipid extraction

2

Lipid Extraction

Folch/Bligh-Dyer methods, phase separation

3

MS Analysis

LC-MS/MS, MALDI imaging, shotgun lipidomics

4

Lipid Identification

LIPID MAPS, Swiss Lipids, LipidBlast

AI-Powered Identification

Machine learning for lipid species identification from MS/MS fragmentation patterns using LipidBlast and custom spectral libraries

Membrane Dynamics

Study membrane curvature, lipid rafts, phase separation, and protein-lipid interactions

Clinical Biomarkers

FDA-cleared ceramide panel for cardiovascular risk, plus emerging biomarkers for NAFLD and diabetes