Gene regulatory network analysis: transcription factors, enhancers, and chromatin architecture
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Regulomics studies gene regulatory networks (GRNs) including transcription factors, enhancers, promoters, and chromatin architecture that control gene expression. The human genome contains ~1600 transcription factors and >1 million regulatory elements. Regulatory mutations cause >90% of GWAS disease variants.
Machine learning algorithms for automated pattern recognition and biomarker discovery
Multi-omics integration for comprehensive biological understanding
Validated biomarkers and therapeutic targets for precision medicine applications